Handling of C. elegans.

Maintenance of C. elegans.

Exception Handling for C++

This paper outlines a design for an exception handling mechanism for C++. It presents the reasoning behind the major design decisions and considers their implications for implementation alternatives. The mechanism is flexible, comparatively safe and easy to use, works in a mixed language execution environment, and can be implemented to run efficiently. Two implementation strategies are describe...

Autophagy in C. elegans.

Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through an autophagosomal-lysosomal pathway. Genetic screens, primarily in S. cerevisiae, have identified numerous genes that are essential for autophagy. Many of these genes have orthologs in higher eukaryotes, including C. elegans, Drosophila, and mammals. Gene knockdown/knockout studies ...

Transgenesis in C. elegans.

The ability to manipulate the genome of organisms at will is perhaps the single most useful ability for the study of biological systems. Techniques for the generation of transgenics in the nematode Caenorhabditis elegans became available in the late 1980s. Since then, improvements to the original approach have been made to address specific limitations with transgene expression, expand on the re...

Chemosensation in C. elegans.

C. elegans has a highly developed chemosensory system that enables it to detect a wide variety of volatile (olfactory) and water-soluble (gustatory) cues associated with food, danger, or other animals. Much of its nervous system and more than 5% of its genes are devoted to the recognition of environmental chemicals. Chemosensory cues can elicit chemotaxis, rapid avoidance, changes in overall mo...